This unique functional dynamics theory/algorithm allows using very few dose-data points to fit the unified general MAL theory, thus to gaining efficiency, cost-effectiveness and automated quantitative simulation. The MAL-PD approach, is an “Up to Down” concept with the unified theory first and applications later. As of, there has been 44,195 downloads by scientists from 137 countries or territories. In 2013, the PD Science LLC was established by Ting-Chao (David) Chou, to take care of scientific affairs of ComboSyn Inc. Researchers who are interested and agree with the terms are welcome to register and download the CompuSyn software along with its User’s Guide free of charge. On August 1st, 2012, the company announced that as the contribution to the bio-medical research communities, the CompuSyn software has been offered for free download upon registration and adherence to the original terms of usage as indicated in the inner conver of the User's Guide. Dorothy Chou in 2005 with purpose of promoting the pharmacodynamic research and simple computerized analytical simulation using the median-effect principle of the mass-action law (2,3) and its combination index theorem (3,4).ĬomboSyn Inc, which always has vision of not-for–profit purpose, had already recovered the software developmental expense and administration cost. The ComboSyn, Inc., the publisher of CompuSyn software (1), which was set up by Dr.
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